Magnetically Controlled Mems Device

ABSTRACT We have developed a magnetically controlled MEMS drug delivery device for on-demand release of defined quantities of an anti-cancer drug, docetaxel DTX. A drug-loaded micro reservoir 6mm550m is sealed by a 40m-thick elastic magnetic PDMS polydimethylsiloxane membrane with a laser-drilled aperture 100100m2.

The MEMS drug delivery device has been used to deliver an antiproliferative, taxane-based drug, docetaxel DTX. On-demand and controlled release of DTX with a dosage suitable for treatment of diabetic retinopathy has been achieved for 35 days.

A magnetically controlled MEMS device for on-demand and controlled drug delivery. Upon application of a magnetic field 250 mT, the membrane deforms, causing discharge of drug solution 171 ngactuation interval from the implant Reproduced with permission from Fig. 1 in 12 2011 Royal Society of Chemistry

We report the development of a magnetically controlled drug delivery device for on-demand drug release to treat chronic diseases. The devices consist of drug-loaded micro-reservoirs 6 mm in diameter and 550 m in depth, sealed by magnetic PDMS polydimethylsiloxane membranes 6 mm 40 m with laser-d

Previously, the concept of electricity-free, magnetically controlled drug delivery devices have been demonstrated in vitro 5, 6 and compared to manually-actuated devices 7. In this work we demonstrate DTX delivery to the ex vivo target eye tissue via the MEMS device Fig. 1.

Request PDF A magnetically controlled MEMS device for drug delivery Design, fabrication, and testing We report the development of a magnetically controlled drug delivery device for on-demand

Novel drug delivery systems based on microtechnology have advanced tremendously, but yet face some technological and societal hurdles to fully achieve their potential. The novel drug delivery systems aim to deliver drugs in a spatiotemporal- and dosage-controlled manner with a goal to address the unmet medical needs from oral delivery and hypodermic injection. The unmet needs include effective

Abstract We report the development of a magnetically controlled MEMS device capable of on-demand release of defined quantities of an antiproliferative drug, docetaxel DTX. Controlled release of DTX with a dosage suitable for the treatment of diabetic retinopathy has been achieved for 35 days.

Abstract We have developed a magnetically controlled MEMS drug delivery device for on-demand release of defined quantities of an anti-cancer drug, docetaxel DTX. A drug-loaded micro reservoir 6mm550m is sealed by a 40m-thick elastic magnetic PDMS polydimethylsiloxane membrane with a laser-drilled aperture 100100m 2. Discharge of the drug solution and the release rates are

In this work, we propose an implantable device of small size SID that is enabled with on-demand, pulsatile drug release without a battery or electronic circuits. The whole body of the device consisted mainly of a drug reservoir that holds approximately 3.3 ml. Inside the body, we prepared a plunger and barrel embedded with magnets.